SOLUT바카라 대박 디시 BRIEF
바카라 대박 디시 and
Reaction 바카라 대박 디시
Ch바카라 대박 디시lenge
Measurement and control of reactions, 바카라 대박 디시 rates and/or amorphous states is increasingly important across the chemical, pharmaceutical and electronics industries. Clear, unambiguous determination of material structure (such as polymorphs), degree of crystallinity, and phase is essential to chemical process development, formulation, stability testing and material characterization. Most measurement modalities require special sample preparation for offline, destructive analysis and can’t provide real-time feedback.
Tradit바카라 대박 디시al Solut바카라 대박 디시s
Observing structur바카라 대박 디시 or phase changes in a materi바카라 대박 디시 can be accomplished sever바카라 대박 디시 ways.Raman spectroscopyis used to observe small band shifts in the “chemical fingerprint” reg바카라 대박 디시 (200 to 1800 cm-1), however these reflect subtle shifts in funct바카라 대박 디시al groups and it is often difficult to detect phase or polymorphic form changes. X-ray diffract바카라 대박 디시 (XRD) techniques have been the industry standard, but require expensive equipment and destructive off-line testing.Terahertz (THz) spectroscopycan differentiate structural changes but is expensive, sensitive to moisture and requires special sample preparat바카라 대박 디시.
Coherent Solut바카라 대박 디시s
Coherent’s THz-Raman® systemsextend the range of traditional Raman spectroscopy to the “structural fingerprint” (also referred to as low frequency, see Fig. 1) region very close to the laser line (5 to 200 cm-1) that corresponds to terahertz vibrational energies while simultaneously collecting “chemical fingerprint” signals. Like ordinary Raman, the process is non-destructive and can be used for real time, in situ process 바카라 대박 디시. As materials change from disordered to highly ordered (e.g. amorphous to crystalline), the low frequency bands shift and become sharper. When changes in polymorphic form, co-crystalline bonds are created or broken, or the degree of hydration is changed, the low wavenumber bands change as well. With up to 10X stronger signals than standard Raman, THz-Raman systems provide fast, unambiguous real-time measurement of crystallization and phase characteristics.
Applicat바카라 대박 디시 Field
Crystallization, polymorphism, phase 바카라 대박 디시, degree of crystallinity, polymorphic transformation, real-time non-destructive structural analysis, low-frequency THz-Raman spectroscopy.
Figure 1:Phase changes in sulfur: The orthorhombic cryst바카라 대박 디시line phase exhibits sharp peaks, indicating a high degree of order in the structure, whereas the the monoclinic form and liquid phases become increasingly disordered, leading to a broadening and ultimate disappearance of the distinctive peaks.
Figure 2:To simulate dynamic process measurements, a commercial Advil tablet was heated then cooled at room temperature while 바카라 대박 디시 the THz-Raman spectra. The active ingredient was initially in an amorphous state, then transitioned to the stable crystalline form after ~15 minutes.
Figure 3:Individual spectra plotted in 5 minute increments for the dynamic process in Figure 2 showing the spectral transit바카라 대박 디시 as the tablet cools.