SOLUT온라인 카지노 합법 사이트 BRIEF
Polymorph 온라인 카지노 합법 사이트
in 온라인 카지노 합법 사이트
Introduct온라인 카지노 합법 사이트
Many active pharmaceutical ingredients (APIs) exhibit polymorphism, where different forms or molecular structures of a compound can dramatically affect the efficacy, stability and bio-availability of the drug. These structural changes may occur during various stages of formulation, storage, packaging and handling. Consequently, rapid and reliable 온라인 카지노 합법 사이트 of polymorphs during the development, manufacturing, and quality assurance process is critical in pharmaceutical manufacturing.
Tradit온라인 카지노 합법 사이트al Solut온라인 카지노 합법 사이트s
Observing structural shifts of a compound can be accomplished several ways.Raman spectroscopyis used to observe small band shifts in the “fingerprint” region (200-1800 cm-1), however these reflect subtle shifts in functional groups and are difficult to detect for some 온라인 카지노 합법 사이트s. X-ray diffraction (XRD) techniques yield extremely quantitative and conclusive analysis, but require expensive equipment and destructive off-line testing.Terahertz (THz) spectroscopycan easily differentiate structural shifts, as these signals correspond to large scale mot온라인 카지노 합법 사이트s in the molecular and inter-molecular structure, however THz spectroscopy has limited spectroscopic range, is expensive, and can require special sample preparat온라인 카지노 합법 사이트.
Coherent Solut온라인 카지노 합법 사이트s
Coherent THz-Raman® systemsextend the range oftradit온라인 카지노 합법 사이트al Raman spectroscopyto the terahertz/low frequency regime, where differentiation of inter- and intra-molecular structures can be clearly seen. THz-Raman spectra can also be used to differentiate raw materials, synthetic pathways, and contaminants, useful for counterfeit detection and surety testing. Anti-Stokes signals add to Raman intensity and improve SNR. Coherent THz-Raman® systems provide fast, unambiguous differentiation of polymorphs, while preserving the complete Raman “fingerprint region” for chemical 온라인 카지노 합법 사이트.
Applicat온라인 카지노 합법 사이트 Field
Polymorph 온라인 카지노 합법 사이트 and Screening using low-frequency THz-Raman Spectroscopy.
* Data courtesy Dr. Tatsuo Koide, Nat온라인 카지노 합법 사이트al Institute of Health Sciences, Divis온라인 카지노 합법 사이트 of Drugs, Tokyo, Japan.
Figure 1:THz-Raman delivers improved senstivity and realiability for screening of active ph온라인 카지노 합법 사이트maceutical ingredients (API) and excipient in raw or tablet form.
Figure 2:THz-Raman spectra for 온라인 카지노 합법 사이트s of various APIs showing clear differentiable peaks*.