BROCHURE
Extending 토토 가상계좌 디시 Into the Thz Domain
Delivering Both Chemical Composition and Structural Infor토토 가상계좌 디시tion in a Single Measurement
Simultaneous Measurement of Both Chemical and Structural Properties
Coherent-patented1 THz-토토 가상계좌 디시™ systemsboost both the efficiency and reliability of materials characterization, in a single, real-time, non-destructive measurement. By unveiling the low-frequency (low wavenumber) range of the 토토 가상계좌 디시 spectrum, often referred to as a secondary “structural fingerprint,” it is possible to directly observe and differentiate key structural properties of materials, while preserving the complete chemical fingerprint.
Key Applications include:
- Differentiation and screening of polymorphs
- Monitoring and quantifying degree of crystallinity
- Characterizing and observing co-crystal for토토 가상계좌 디시tion
- Process monitoring and analysis of chemical reactions
- Characterizing thickness and orientation of few-layer nano토토 가상계좌 디시terials
- Structural characterization of polymers
- Explosives detection and analysis, including determination of formulation methods
The THz-토토 가상계좌 디시 region (±5 cm-1 to 200 cm-1) corresponds to the 토토 가상계좌 디시-energy vibrations (150 GHz to 6 토토 가상계좌 디시) of inter-molecular/intra-molecular vibrations, including phonon modes, lattice modes, and rotational modes. These are often 5 to 10 times stronger than normal vibrational modes, significantly boosting signal strength. By capturing both Stokes and anti-Stokes signals, spectral features can be validated and the excitation wavelength (0 cm-1) can be precisely determined due to signal symmetry, eliminating the need for system re-calibration.
Figure 1:Benchtop THz-토토 가상계좌 디시 Module
THz-토토 가상계좌 디시 Spectroscopy Modules are designed as integrated, ultra-compact, plug-and-play solutions to upgrade your existing 토토 가상계좌 디시 spectrometer. Comprising an ultra-narrowband ASE-free laser source, NoiseBlock™ 90/10 beamsplitter, and dual-stage SureBlock™ notch filters, the system delivers OD9 Rayleigh attenuation and signal capture of both Stokes and anti-Stokes signals down to 5 cm-1. (Figure 1)
Figure 2:THz-토토 가상계좌 디시 spectra of Carbamazepine shows clearly differentiated polymorphic and hydrated forms.²
System Configurations
AllTR-SeriesTHz-토토 가상계좌 디시 modules are ultra-compact and simple to connect via fiber to almost any spectrometer or 토토 가상계좌 디시 system. A high-power, wavelength-stabilized, single-frequency laser source is precisely matched to the ultra narrow-band ASE, beamsplitter and notch filters to assure maximum throughput and exceptional attenuation (OD 9) of the excitation source. Systems are available in 532 nm, 633 nm, 785 nm, and 808 nm excitation wavelengths.
TheTR-PROBEis a compact, robust THz-토토 가상계좌 디시 probe that enables in-situ reaction or process monitoring, and can also be flexibly configured with a variety of sample interface accessories, including immersion or contact probe tips, a convenient vial/tablet holder, a Transmission 토토 가상계좌 디시 adapter, a microscope mount, or a steerable non-contact optic (see options below). A separate CleanLine™ laser provides ASE-free excitation via a multimode fiber, enabling the probe to operate in harsher environments where electrical connections are not permitted. Options include circular polarization or a dual-port/dual polarization output for simultaneous measurement of both S and P polarizations.
TheTR-BENCHis configured for benchtop use and offers a similar range of interchangeable sample interface accessories holder for fast, easy measurements. The system also comes with a standard cage mounting plate (centered on the collimated output beam) to allow for customized collection optics or easy integration 토토 가상계좌 디시 a customized system. Options include circular polarization or a dual-port/dual polarization output for simultaneous measurement of both S and P polarizations.
TheTR-MICROmounts directly to a broad range of popular microscope platforms and micro-토토 가상계좌 디시 systems, and can be easily switched in and out of the optical path. Linear polarization is standard, circular polarization is optional.
THz-토토 가상계좌 디시 modules are compatible with virtually any commercial 토토 가상계좌 디시 system or spectrometer, and Coherent can recommend or integrate an appropriate spectrometer and deliver as a complete turnkey system.
A variety of sample interface accessories enable the TR-PROBE and TR-BENCH to be easily configured to match a broad range of applications. Immersion or contact probe tips may be mounted with either a fixed SwageLok mount, or for longer probes that may need alignment, an adjustable tip/tilt probe mount. The Vial/Tablet Sample Holder incorporates an adjustable steering mirror, interchangeable focusing lens, and safety shutter, and the Steerable Non-contact Optic Mount allows for projection and steering of the output beam with precision alignment and interchangeable focusing optics, for applications requiring long-range collection paths. New accessories include a Transmission 토토 가상계좌 디시 adapter (Probe only) which is ideal for bulk sampling of tablets or vials, and a Microscope mount with in/out optical switching and beam steering adjustments.
THz-토토 가상계좌 디시 Applications Examples
Crystal Monitoring and AnalysisIdentifying and monitoring the formation of cocrystals is also improved using THz-토토 가상계좌 디시 spectra. The figure above shows the clearly recognizable peak shifts that occur when cocrystals are formed in a mixture of Caffeine and 2-Benzoic acid.
Gas SensingRotational modes of many gases can be clearly seen in the THz-토토 가상계좌 디시 region. Signal intensities can be up to 10x those in the fingerprint region, opening up the possibility of using 토토 가상계좌 디시 for extremely sensitive gas sensing applications. The Stokes/anti-Stokes ratios can also be used for in-situ sensing of temperature.
Polymorph IdentificationPolymorphic forms and hydrates of phar토토 가상계좌 디시ceuticals can easily be distinguished in raw 토토 가상계좌 디시terials analysis, finished goods, process monitoring, and QC applications.
Phase MonitoringPhase changes of Sulfur observed when heated from room temp.(α) to 95.2°C (β) and then to the melting point of 115.21°C (λ). Note the clearly recognizable changes in peak location, shape and magnitude in the THz-토토 가상계좌 디시 region. Crystalline phases result in sharp peaks, which broaden and dissipate as the sulfur liquifies.
Phase MonitoringLow frequency spectra can be used to monitor transformation of polymorphs. The waterfall plot above shows anhydrous theophylline before and after its transformation 토토 가상계좌 디시 a flocculated slurry, over a period of approximately 100 seconds. (data courtesy Clairet Scientific Ltd.)
Synthetic Pathway Analysis: Explosives ForensicsMultiple samples of ETN (Erythritol Tetranitrate), representing syste토토 가상계좌 디시tic variations of ingredients and preparation routes, show distinctive differences.
1 US Patents 7,986,407 and 8,184,285.
2 Data taken using SureBlock™ notch filters and a single-stage spectrometer at 785 nm.
